Need for research and development

Traditionally, clinical research focuses on subjective evaluation of the physiological meaning of the shades of gray constituting an image. Quantitative analysis of combined multi modal images provides a more objective basis for clinical decision-making. Currently, there is a lack of tools for quantification and integration of these data. iQ will study physiological and molecular mechanisms underlying changes in the contrast of images and develop clinically validated tools and protocols to allow for quantification on a routine basis. Optical methods, based on natural and exogenous (e.g. fluorescence) contrast, can be implemented to guide therapy and set diagnosis by in vivo optical biopsies. State-of-the-art mathematical modeling is required to create images of (moving) tissue that can easily be interpreted by health care professionals. A major challenge is the integration of microscopic and macroscopic imaging techniques.